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Magnesium Research 1991, 4, 3/4, 246.

Regional distribution of magnesium in the cerebral tissues in normal and magnesium deficient rat

S. Poenaru, P. Aymard, J. Durlach, R. Manicom, L. Poenaru, S. Rouhani, Y. Rayssiguier, E. Emmanouilidis, E. Gueux, N. Nkanga, A. Soulairac

Laboratoire de Neuroendocrinologie, UFR Biomédicale des Saints-Pères, 45 rue des Saints-Pères, 75006 Paris, France

Experiments were carried out for forty days in two groups of male Wistar rats: a study group of 12 rats made magnesium-deficient (MD), and a control group (CG) of 12 rats fed normal diet.

The magnesium-deficient diet contained 20% casein, 70.5% starch, 5% maize oil, 3.5% mineral mix and 1% vitamin mix. The magnesium content was 50 milligrams per kilogram of food. The normal diet had the same composition but was supplemented with magnesium oxide increasing the magnesium content to 1 gram per kilogram of food.

We used the technique of Glowinski and Iversen with our own modifications. Immediately after decapitation, rat brains were cooled and finely dissected.

We isolated twelve cerebral structures: the brain stem (B.S.) cerebellum (CB), hypothalamus (HT), thalamus (T), inferior and superior colliculi (CIF and CS), olfactory bulb (OB), tuberculum olfactorium (OTU), septum (S), hippocampus (Hi), cortex piriformis (PIR), corpus striatum (CST) and the cortex (C).

Tissue content of magnesium was carried out with the technique of MacIntyre & Davidson. In the magnesium-deficient group we noted the clinical and biological signs of experimental magnesium deficiency. In the control group intracerebral magnesium level varies, with a maximum of 27%, from 133.24 to 168.81 µg/g. In the magnesium group a 35 % maximum variation was noted (from 121.00 to 164.40 µg/g).

The topographic distribution reveals higher Mg2+ level in OTU, CST and T in control group and in CIF and CS in deficient group. The lower Mg2+ level was observed in control group in CG, in HT, CIF and CS, OB, S and C while in deficient group only in S and C.

Our study stresses that:

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This page was first uploaded to The Magnesium Web Site on February 4, 1996