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This paper outlines the in vivo interaction between magnesium and fluoride, and offers a coherent, comprehensive theory of the underlying biochemical cause of fibromyalgia and chronic fatigue syndrome.

A Nutrient/Toxin Interaction Theory of the Etiology and Pathogenesis of Chronic Pain-Fatigue Syndromes, Parts I and II

Laylander JA

Journal of Chronic Fatigue Syndrome, vol. 5, no. 1, 1999, pages 67-126.

Abstract: Recent research suggests that Chronic Fatigue Syndrome (CFS), Fibromyalgia Syndrome (FMS), and Persian Gulf Syndrome (PGS) may respresent the effects of dysfunctions involving the central and/or peripheral nervous system, neuroendocrine system, neuromuscular system, immune system, metabolism, or sleep patterns. Each systemic dysfunction is accepted here as being central to these syndromes but not causal. This two-part review introduces the theory that the syndromes listed above represent finitely variable combinations of multiple systemic dysfunctions which all share a common underlying etiology at the subcellular level: magnesium deficiency plus concomitant fluoride excess (MDFE). The theory is introduced in Part I; detailed evidence which supports the theory is presented in Part II. Treatment suggestions are listed at the end of Part II through a call for clinical trials to test this theory.

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